Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.

Abstract

The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis--the agent that causes tuberculosis (TB)--to spread. The current paradigm proposes that this destruction occurs as a result of the action of proinflammatory cytokines, chemokines, immune cells, and lipids that mediate TB-associated necrosis in the lung. However, this view… (More)
DOI: 10.1126/scitranslmed.3001847

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Cite this paper

@article{Elkington2011TuberculosisIT, title={Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.}, author={Paul T Elkington and Jeanine M D'armiento and Jon S Friedland}, journal={Science translational medicine}, year={2011}, volume={3 71}, pages={71ps6} }