Tuberculosis drug discovery in the post-post-genomic era

  title={Tuberculosis drug discovery in the post-post-genomic era},
  author={Benoit Lechartier and Jan Rybniker and Alimuddin M. Zumla and Stewart T Cole},
  booktitle={EMBO molecular medicine},
The expectation that genomics would result in new therapeutic interventions for infectious diseases remains unfulfilled. In the post-genomic era, the decade immediately following the availability of the genome sequence of Mycobacterium tuberculosis, tuberculosis (TB) drug discovery relied heavily on the target-based approach but this proved unsuccessful leading to a return to whole cell screening. Genomics underpinned screening by providing knowledge and many enabling technologies, most… CONTINUE READING
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