Tuberculosis chemotherapy in the 21st century: Back to the basics

@article{Joshi2011TuberculosisCI,
  title={Tuberculosis chemotherapy in the 21st century: Back to the basics},
  author={J. Joshi},
  journal={Lung India : Official Organ of Indian Chest Society},
  year={2011},
  volume={28},
  pages={193 - 200}
}
  • J. Joshi
  • Published 2011
  • Medicine
  • Lung India : Official Organ of Indian Chest Society
The key to successful elimination of tuberculosis (TB) is treatment of cases with optimum chemotherapy. Poor chemotherapy over time has led to drug-resistant disease. Drug resistance of Mycobacterium tuberculosis develops by the selective growth of resistant mutants. The incidence of drug-resistant cases depends on the number of bacilli and the drug-resistant mutants in the lesion. The latter is low for individual drugs and even lower for two and three drugs. Therefore, use of combination… Expand
Drug targets exploited in Mycobacterium tuberculosis: Pitfalls and promises on the horizon.
Analysing non-synonymous mutations in XDR and MDR tuberculosis drugs
Extrapulmonary drug-resistant tuberculosis at a drug-resistant tuberculosis center, Mumbai: Our experience – Hope in the midst of despair!
  • U. Desai, J. Joshi
  • Medicine
  • Lung India : official organ of Indian Chest Society
  • 2019
Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance
Cell wall: A versatile fountain of drug targets in Mycobacterium tuberculosis.
Role of RNTCP in the management of MDR-TB
...
1
2
3
4
5
...