Tuberculosis and cancer: parallels in host responses and therapeutic approaches?

@article{Grange1995TuberculosisAC,
  title={Tuberculosis and cancer: parallels in host responses and therapeutic approaches?},
  author={John M. Grange and John L. Stanford and Graham A. W. Rook},
  journal={Lancet},
  year={1995},
  volume={345 8961},
  pages={1350-2}
}
Mycobacteria elicit two quite different immune responses. One is protective and is partly based on recognition and lysis of stressed, bacilli-laden cells expressing heat-shock proteins. The other suppresses this recognition and instead leads to indiscriminate necrosis of tissues containing mycobacteria (the Koch phenomenon). The type of response depends on the predominant T-cell maturation pathway, Th1 or Th2, which in turn is determined by priming by prior contact with environmental… CONTINUE READING