Tuberculosis Recurrence and Mortality after Successful Treatment: Impact of Drug Resistance

  title={Tuberculosis Recurrence and Mortality after Successful Treatment: Impact of Drug Resistance},
  author={Helen Suzanne Cox and Yared Kassahun Kebede and Sholpan Allamuratova and Gafurzhan Ismailov and Zamira Davletmuratova and Graham Byrnes and Christine Stone and Stefan Niemann and Sabine Ruesch-Gerdes and Lucie Blok and Daribay Doshetov},
  journal={PLoS Medicine},
  pages={1009 - 1021}
BACKGROUND The DOTS (directly observed treatment short-course) strategy for tuberculosis (TB) control is recommended by the World Health Organization globally. However, there are few studies of long-term TB treatment outcomes from DOTS programs in high-burden settings and particularly settings of high drug resistance. A DOTS program was implemented progressively in Karakalpakstan, Uzbekistan starting in 1998. The total case notification rate in 2003 was 462/100,000, and a drug resistance survey… CONTINUE READING
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