Early immune events in Mycobacterium tuberculosis infection and vaccination: protective role for GM-CSF in the primary immune response to Mycobacterium tuberculosis infection and recall responses following vaccination
- Biology, Medicine
Overall this thesis demonstrates the importance ofGM-CSF in the primary and recall responses to Mtb infection and identifies ILCs as an early, innate source of GM- CSF.
Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV‐positive individuals
- MedicineThe Cochrane database of systematic reviews
The diagnostic accuracy of abdominal ultrasound for detecting abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals was determined to investigate potential sources of heterogeneity in test accuracy, including clinical setting, ultrasound training level, and type of reference standard.
Design issues and extensions of multi-arm multi-stage clinical trials
The MAMS design, which compares multiple new treatments against a control in a single trial, obviating the need for multiple two-arm studies, and ceases recruitment to poorly performing arms during the study is extended to other types of outcome measure such as binary.
Systemic Manifestation of Miliary Tuberculosis in Patient With Advanced Diabetic Retinopathy Presenting With Electrolyte Imbalance, Seizures, and Adrenal Insufficiency
A 50-year-old man of South Asian origin who presented with acute adrenal crisis on a background of undiagnosed miliary tuberculosis and remains well on anti-tuberculous chemotherapy, corticosteroids, and anti-epileptic medication is described.
A case of concurrent gastrointestinal, peritoneal and urinary bladder tuberculosis
- MedicineIndian Journal of Tuberculosis
Abnormal Tryptophan Metabolism in HIV and Mycobacterium tuberculosis Infection
- Biology, MedicineFrontiers in Microbiology
The recent advances regarding abnormal tryptophan metabolism in HIV and Mycobacterium tuberculosis infection are highlighted and its potential impact on immune regulation, disease progression, and neurological disorders is discussed.
Acute tubulointerstitial nephritis in a patient with early bronchial tuberculosis.
- Medicine, BiologyJournal of the Formosan Medical Association = Taiwan yi zhi
Association of TAP1 1177A>G and 2090A>G gene polymorphisms with latent tuberculosis infections in sheltered populations, in the metropolitan area of Guadalajara, Mexico: a pilot study
- BiologyRevista do Instituto de Medicina Tropical de Sao Paulo
The results suggest that carriers of the G allele of rs1135216 (A>G) are susceptible to LTBI, according to the codominant genetic model.
Gene Xpert/MTB RIF assay for spinal tuberculosis- sensitivity, specificity and clinical utility.
- Medicine, BiologyJournal of clinical orthopaedics and trauma
Inflammatory Determinants of Differential Tuberculosis Risk in Pre-Adolescent Children and Young Adults
- MedicineFrontiers in Immunology
The findings suggest that myeloid inflammation is intrinsically lower in pre-pubescent children than in young adults, and the lower or more regulated pro-inflammatory responses may play a role in the lower risk of TB disease in this age group.
SHOWING 1-10 OF 151 REFERENCES
Linezolid for multidrug-resistant tuberculosis.
- Medicine, BiologyThe Lancet. Infectious diseases
Model-Based Estimates of the Effects of Efavirenz on Bedaquiline Pharmacokinetics and Suggested Dose Adjustments for Patients Coinfected with HIV and Tuberculosis
- Biology, MedicineAntimicrobial Agents and Chemotherapy
The results suggest that simple adjustments of the standard regimen during EFV coadministration can prevent reduced exposure to BDQ without increasing exposures to M2, however, exposure to M3 would increase.
Provisional CDC guidelines for the use and safety monitoring of bedaquiline fumarate (Sirturo) for the treatment of multidrug-resistant tuberculosis.
- MedicineMMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports
This report provides provisional CDC guidelines for FDA-approved and unapproved, or off-label, uses of bedaquiline in certain populations, such as children, pregnant women, or persons with extrapulmonary MDR TB who were not included in the clinical trials for the drug.
The use of Xpert MTB / RIF assay for the detection of pulmonary and extrapulomnary tuberculosis and rifampicin resistance in adults and children
World Health Organization. Interim guidance on the use of bedaquiline to treat MDR-TB
Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients
- Medicine, BiologyEuropean Respiratory Journal
It is indicated that the LAM strip-test may be a potentially useful rapid rule-in test for TB in hospitalised patients with advanced immunosuppression and the grade 2, but not the manufacturer-recommended grade 1 cut-off point, offered superior rule- in utility and inter-reader reliability.
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis
- Medicine, BiologyEuropean Respiratory Journal
The study results suggest an excellent efficacy but also the necessity of caution in the prescription of linezolid, and the proportion of adverse events was significantly higher when the lineZolid daily dosage exceeded 600 mg.
Fluoroquinolones for the Treatment of Pulmonary Tuberculosis
- Medicine, BiologyDrugs
The review of the literature does not support the use of older fluoroquinolones, especially ciprofloxacin, as substitute agents for drug-sensitive or drug-resistant TB, however, newer fluoroquolone, such as moxifloxacins, may be a reasonable alternative based on results from one large clinical trial.
High Diagnostic Yield of Tuberculosis From Screening Urine Samples From HIV-Infected Patients With Advanced Immunodeficiency Using The Xpert MTB/RIF Assay
- Medicine, BiologyJournal of acquired immune deficiency syndromes
Urine Xpert testing provides a means of rapid TB diagnosis in patients with advanced immunodeficiency and poor prognosis and is indicative of high rates of TB dissemination and renal involvement in this clinical population.
Linezolid for the treatment of complicated drug-resistant tuberculosis: a systematic review and meta-analysis.
- Medicine, BiologyThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Treatment success with linezolid was equal to or better than that commonly achieved for uncomplicated DR-TB, and better than previous reports for previously treated patients and those with XDR-TB.