Tuberculosis Control in South African Gold Mines: Mathematical Modeling of a Trial of Community-Wide Isoniazid Preventive Therapy

@article{Vynnycky2015TuberculosisCI,
  title={Tuberculosis Control in South African Gold Mines: Mathematical Modeling of a Trial of Community-Wide Isoniazid Preventive Therapy},
  author={Emilia Vynnycky and Tom Sumner and Katherine L. Fielding and James J. Lewis and Andrew P. Cox and Richard J. Hayes and Elizabeth Lucy Corbett and Gavin J Churchyard and Alison D. Grant and Richard G. White},
  journal={American Journal of Epidemiology},
  year={2015},
  volume={181},
  pages={619 - 632}
}
A recent major cluster randomized trial of screening, active disease treatment, and mass isoniazid preventive therapy for 9 months during 2006–2011 among South African gold miners showed reduced individual-level tuberculosis incidence but no detectable population-level impact. We fitted a dynamic mathematical model to trial data and explored 1) factors contributing to the lack of population-level impact, 2) the best-achievable impact if all implementation characteristics were increased to the… 

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