Tuberculosis: global approaches to a global disease.

@article{Kirschner2010TuberculosisGA,
  title={Tuberculosis: global approaches to a global disease.},
  author={Denise E. Kirschner and Douglas Brownlee Young and JoAnne L. Flynn},
  journal={Current opinion in biotechnology},
  year={2010},
  volume={21 4},
  pages={
          524-31
        }
}
Mycobacterium tuberculosis is a remarkably successful human pathogen. The interaction with the human host is complex and much remains unknown. Recent advances in systems biology have allowed the integration of data from humans and animal models into computational approaches. For example, mathematical models provide a platform for in silico manipulation of host-pathogen interactions to gain insight into this infection across temporal and biologic scales. Here, we review recent studies on global… CONTINUE READING
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