Tuberculin reactivity after newborn BCG immunization in mono- and dizygotic twins.

@article{Seplveda1994TuberculinRA,
  title={Tuberculin reactivity after newborn BCG immunization in mono- and dizygotic twins.},
  author={R L Sep{\'u}lveda and I M Heiba and Cristina Navarrete and Robert C. Elston and Benito Gonzalez and Ricardo U. Sorensen},
  journal={Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  year={1994},
  volume={75 2},
  pages={138-43}
}
SETTING Studies showing significantly higher concordance of tuberculosis among monozygotic twins than dizygotic twins have provided support for genetically determined susceptibility to tuberculosis. OBJECTIVE We wished to explore whether the development of delayed type hypersensitivity to tuberculin after newborn BCG immunization of twins suggested genetic regulation of the response to BCG in humans. DESIGN Our study population consisted of 17 monozygotic twin pairs, 18 dizygotic twin pairs… CONTINUE READING