Tubeimoside-1 induces G2/M phase arrest and apoptosis in SKOV-3 cells through increase of intracellular Ca²⁺ and caspase-dependent signaling pathways.

@article{Chen2012Tubeimoside1IG,
  title={Tubeimoside-1 induces G2/M phase arrest and apoptosis in SKOV-3 cells through increase of intracellular Ca²⁺ and caspase-dependent signaling pathways.},
  author={Wen-juan Chen and Chao Yu and Zhu Yang and Jun-lin He and Juan Yin and Hai-Zhong Liu and Hongtao Liu and Ying-xiong Wang},
  journal={International journal of oncology},
  year={2012},
  volume={40 2},
  pages={
          535-43
        }
}
Tubeimoside-1 (TBMS1) extracted from Bolbostemma paniculatum (Maxim), is a traditional Chinese herb with anticancer potential. It induces apoptosis in a number of human carcinoma cell lines, but the mechanism has remained unclear. In the present study, we investigated the pro-apoptotic activity of TBMS1 against SKOV-3 cell lines and the underlying mechanisms. Treatment with TBMS1 resulted in dose- and time-dependent inhibition of proliferation, led to arrest in phase G2/M of the cell cycle and… CONTINUE READING

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