Tubedown-1, a novel acetyltransferase associated with blood vessel development.

@article{Gendron2000Tubedown1AN,
  title={Tubedown-1, a novel acetyltransferase associated with blood vessel development.},
  author={Robert L. Gendron and Lisa C Adams and H{\'e}l{\`e}ne Paradis},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2000},
  volume={218 2},
  pages={300-15}
}
We have used an embryonic endothelial cell line (IEM cells) as an experimental system for identifying and characterizing new molecules which are regulated during blood vessel development. A novel gene isolated from IEM cells, tubedown-1 (tbdn-1), is expressed at high levels in unstimulated IEM cells and is downregulated during formation of capillary tube structures by the IEM cells induced by basic fibroblast growth factor (bFGF) and leukemia inhibitory factor (LIF) in vitro. Tbdn-1 is also… CONTINUE READING