Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity.

@article{Towb2009TubeIA,
  title={Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity.},
  author={Par Towb and Huaiyu Sun and Steven A. Wasserman},
  journal={Journal of innate immunity},
  year={2009},
  volume={1 4},
  pages={309-21}
}
Acting through the Pelle and IRAK family of protein kinases, Toll receptors mediate innate immune responses in animals ranging from insects to humans. In flies, the Toll pathway also functions in patterning of the syncytial embryo and requires Tube, a Drosophila -specific adaptor protein lacking a catalytic domain. Here we provide evidence that the Tube, Pelle, and IRAK proteins originated from a common ancestral gene. Following gene duplication, IRAK-4, Tube-like kinases, and Tube diverged… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 67 references

Overview of innate immunity in Drosophila.

Journal of biochemistry and molecular biology • 2005

Similar Papers

Loading similar papers…