Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.

@article{Caberoy2010TubbyAT,
  title={Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.},
  author={Nora Blanca Caberoy and Yixiong Zhou and Wei Li},
  journal={The EMBO journal},
  year={2010},
  volume={29 23},
  pages={3898-910}
}
Tubby and tubby-like protein 1 (Tulp1) are newly identified phagocytosis ligands to facilitate retinal pigment epithelium (RPE) and macrophage phagocytosis. Both proteins without classical signal peptide have been demonstrated with unconventional secretion. Here, we characterized them as novel MerTK ligands to facilitate phagocytosis. Tulp1 interacts with Tyro3, Axl and MerTK of the TAM receptor tyrosine kinase subfamily, whereas tubby binds only to MerTK. Excessive soluble MerTK extracellular… CONTINUE READING
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