Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls.

@article{Mingels2012TubalEL,
  title={Tubal epithelial lesions in salpingo-oophorectomy specimens of BRCA-mutation carriers and controls.},
  author={Marjanka Jjm Mingels and Thijs Roelofsen and Jeroen van der Laak and Joanne A de Hullu and Maaike A van Ham and Leon Fag Massuger and Johan Bulten and Mijke Bol},
  journal={Gynecologic oncology},
  year={2012},
  volume={127 1},
  pages={
          88-93
        }
}
OBJECTIVE A precursor lesion for ovarian carcinoma, tubal intraepithelial carcinoma (TIC), has been identified in BRCA-mutation carriers undergoing prophylactic bilateral salpingo-oophorectomy (pBSO). Other lesions were also identified in fallopian tubes, but different terminology, interpretation, and lack of knowledge of normal epithelium, have hampered to unravel their possible role in carcinogenesis. The aim of this study is to classify tubal epithelial lesions in BRCA-mutation carriers and… CONTINUE READING
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