Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.

@article{AldanaMasangkay2011TubacinSP,
  title={Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.},
  author={Grace I. Aldana-Masangkay and Agust{\'i}n Rodr{\'i}guez-Gonz{\'a}lez and Tara L Lin and Alan K. Ikeda and Yao-Te Hsieh and Yong-mi Kim and Brett Lomenick and Kazuo Okemoto and Elliot M. Landaw and Dongpeng Wang and Ralph Mazitschek and James E. Bradner and Kathleen M Sakamoto},
  journal={Leukemia & lymphoma},
  year={2011},
  volume={52 8},
  pages={1544-55}
}
Over the past decade, histone deacetylase inhibitors have increasingly been used to treat various malignancies. Tubacin (tubulin acetylation inducer) is a small molecule that inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin. We observed a higher antiproliferative effect of tubacin in acute lymphoblastic leukemia (ALL) cells than in normal hematopoietic cells. Treatment with tubacin led to the induction of apoptotic pathways in both pre-B and T cell ALL cells at a 50… CONTINUE READING
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HDAC6 and its role in cancer

  • GI Aldana-Masangkay, KM Sakamoto
  • J Biomed Biotech 2011;2011:875824
  • 2011
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