Tuba stimulates intracellular N-WASP-dependent actin assembly.

  title={Tuba stimulates intracellular N-WASP-dependent actin assembly.},
  author={E. M. Kovacs and Robert S Makar and Frank B. Gertler},
  journal={Journal of cell science},
  volume={119 Pt 13},
Tuba is a multidomain scaffolding protein that links cytoskeletal dynamics and membrane trafficking pathways. The N-terminus of Tuba binds dynamin1, and the C-terminus contains domains that can interact with signaling pathways and cytoskeletal regulatory elements. We investigated Tuba localization, distribution and function in B16 melanoma cells. Tuba overexpression stimulated dorsal ruffles that occurred independently of dynamin function. Tuba expression induced actin-driven motility of small… CONTINUE READING


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