Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

@article{Esguerra2007TtrapIA,
  title={Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.},
  author={Camila V. Esguerra and Luc Nelles and Liesbeth Vermeire and Abdelilah Ibrahimi and Alexander D. Crawford and Rita Derua and Els D R Janssens and Etienne Waelkens and Peter Carmeliet and D{\'e}sir{\'e} Collen and Danny Huylebroeck},
  journal={Development},
  year={2007},
  volume={134 24},
  pages={4381-93}
}
During vertebrate development, signaling by the TGFbeta ligand Nodal is critical for mesoderm formation, correct positioning of the anterior-posterior axis, normal anterior and midline patterning, and left-right asymmetric development of the heart and viscera. Stimulation of Alk4/EGF-CFC receptor complexes by Nodal activates Smad2/3, leading to left-sided expression of target genes that promote asymmetric placement of certain internal organs. We identified Ttrap as a novel Alk4- and Smad3… CONTINUE READING