Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain

@inproceedings{Anguera2011TsxPA,
  title={Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain},
  author={Montserrat C Anguera and Weiyuan Ma and Danielle E Clift and Satoshi Namekawa and Raymond J. Kelleher and Jeannie T Lee},
  booktitle={PLoS genetics},
  year={2011}
}
The Tsx gene resides at the X-inactivation center and is thought to encode a protein expressed in testis, but its function has remained mysterious. Given its proximity to noncoding genes that regulate X-inactivation, here we characterize Tsx and determine its function in mice. We find that Tsx is actually noncoding and the long transcript is expressed robustly in meiotic germ cells, embryonic stem cells, and brain. Targeted deletion of Tsx generates viable offspring and X-inactivation is only… CONTINUE READING
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