TssA forms a gp6‐like ring attached to the type VI secretion sheath

@inproceedings{Planamente2016TssAFA,
  title={TssA forms a gp6‐like ring attached to the type VI secretion sheath},
  author={Sara Planamente and Osman Salih and Eleni N Manoli and David Albesa-Jov{\'e} and Paul S. Freemont and Alain Filloux},
  booktitle={The EMBO journal},
  year={2016}
}
The type VI secretion system (T6SS) is a supra-molecular bacterial complex that resembles phage tails. It is a killing machine which fires toxins into target cells upon contraction of its TssBC sheath. Here, we show that TssA1 is a T6SS component forming dodecameric ring structures whose dimensions match those of the TssBC sheath and which can accommodate the inner Hcp tube. The TssA1 ring complex binds the T6SS sheath and impacts its behaviour in vivo In the phage, the first disc of the gp18… CONTINUE READING