Tsr Chemoreceptor Interacts With IL-8 Provoking E. coli Transmigration Across Human Lung Epithelial Cells

@article{Han2016TsrCI,
  title={Tsr Chemoreceptor Interacts With IL-8 Provoking E. coli Transmigration Across Human Lung Epithelial Cells},
  author={B. Han and Manshu Li and Yonghao Xu and D. Islam and Julie Khang and L. Del Sorbo and W. Lee and K. Sz{\'a}szi and N. Zhong and Arthur S Slutsky and Yimin Li and Haibo Zhang},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
Bacterial colonization of epithelial surfaces and subsequent transmigration across the mucosal barrier are essential for the development of infection. We hypothesized that the methyl-accepting proteins (MCPs), known as chemoreceptors expressed on Escherichia coli (E. coli) bacterial surface, play an important role in mediating bacterial transmigration. We demonstrated a direct interaction between human interleukin-8 (IL-8) and Tsr receptor, a major MCP chemoreceptor. Stimulation of human lung… Expand

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