Tsix Transcription- versus RNA-Based Mechanisms in Xist Repression and Epigenetic Choice

@article{Shibata2004TsixTV,
  title={Tsix Transcription- versus RNA-Based Mechanisms in Xist Repression and Epigenetic Choice},
  author={Shinwa Shibata and Jeannie T Lee},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={1747-1754}
}
Recent inquiries have revealed a surprisingly large number (>2500) of naturally occurring antisense transcripts, but their function remains largely undiscovered. A better understanding of antisense mechanisms is clearly needed because of their potentially diverse roles in gene regulation and disease. A well-documented case occurs in X inactivation, the mechanism by which X-linked gene expression is equalized between XX females and XY males. The antisense gene Tsix determines X chromosome choice… CONTINUE READING

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