Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.

@article{Gable2000Tsc3pIA,
  title={Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity.},
  author={Ken Gable and H Slife and Dagmar Bac{\'i}kov{\'a} and E. J. Monaghan and Teresa M. Dunn},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 11},
  pages={7597-603}
}
Serine palmitoyltransferase catalyzes the first step of sphingolipid synthesis, condensation of serine and palmitoyl CoA to form the long chain base 3-ketosphinganine. The LCB1/TSC2 and LCB2/TSC1 genes encode homologous proteins of the alpha-oxoamine synthase family required for serine palmitoyltransferase activity. The other alpha-oxoamine synthases are soluble homodimers, but serine palmitoyltransferase is a membrane-associated enzyme composed of at least two subunits, Lcb1p and Lcb2p. Here… CONTINUE READING