Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma

@inproceedings{Guo2014Tsc1Tp53LI,
  title={Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma},
  author={Yanan Guo and Lucian R. Chirieac and Raphael Bueno and Harvey I. Pass and Wenhao Wu and Izabela Agata Malinowska and David J Kwiatkowski},
  booktitle={Oncogene},
  year={2014}
}
Mesothelioma is diagnosed in ∼2500 patients in the United States every year, most often arising in the pleural space, but also occurring as primary peritoneal mesothelioma. The vast majority of patients with mesothelioma die of their disease within 3 years. We developed a new mouse model of mesothelioma by bladder or intraperitoneal injection of adenovirus Cre into mice with conditional alleles of each of Tp53 and Tsc1. Such mice began to develop malignant ascites about 6 months after injection… CONTINUE READING
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