Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression.

@article{Comai2016TryptophanVS,
  title={Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: markers for aggression.},
  author={Stefano Comai and Antonella Bertazzo and Jeanne Vachon and Marc S. Daigle and J. -M. Toupin and Gilles C{\^o}t{\'e} and Gustavo Turecki and Gabriella Gobbi},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2016},
  volume={70},
  pages={8-16}
}
Aggressive behavior is one of the most challenging symptoms in psychiatry, and biological markers for aggression lack of large sample validations. Serotonin (5-HT) and other neuroactive compounds deriving from Tryptophan (Trp), including kynurenine (Kyn), have not yet been investigated in large cohorts of aggressive individuals to validate their potential as biomarkers of aggression. In 361 male inmates we measured serum levels of Trp, 5-hydroxytryptophan, 5-HT, Kyn, the ratios 5-HT/Trp∗1000… CONTINUE READING
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User’s Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders—Research Version

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