Tryptophan prototrophy contributes to Francisella tularensis evasion of gamma interferon-mediated host defense.

@article{Chu2011TryptophanPC,
  title={Tryptophan prototrophy contributes to Francisella tularensis evasion of gamma interferon-mediated host defense.},
  author={Ping Chu and Annette R. Rodriguez and Bernard. P. Arulanandam and Karl Klose},
  journal={Infection and immunity},
  year={2011},
  volume={79 6},
  pages={2356-61}
}
Francisella tularensis is able to survive and replicate within host macrophages, a trait that is associated with the high virulence of this bacterium. The trpAB genes encode the enzymes required for the final two steps in tryptophan biosynthesis, with TrpB being responsible for the conversion of indole to tryptophan. Consistent with this function, an F. tularensis subsp. novicida trpB mutant is unable to grow in defined medium in the absence of tryptophan. The trpB mutant is also attenuated for… CONTINUE READING
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