Tryptophan metabolism and immunogenetics in major depression: a role for interferon-γ gene.

Abstract

The tryptophan metabolism and immune activation play a role in pathophysiology of major depressive disorders. The pro-inflammatory cytokine interferon-γ transcriptionally induces the indoleamine 2,3-dioxygenase enzyme that degrades the tryptophan and thus induces serotonin depletion. The polymorphism of certain cytokine genes was reported to be associated… (More)
DOI: 10.1016/j.bbi.2013.04.003

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