Tryptophan loading induces oxidative stress.

  title={Tryptophan loading induces oxidative stress.},
  author={C M Forrest and Gillian M. Mackay and Nicholas Stoy and Martyn Egerton and John A. Christofides and Trevor W Stone and Lynda Gail Darlington},
  journal={Free radical research},
  volume={38 11},
In previous studies tryptophan loads have been administered to human subjects in order to raise central levels of 5-hydroxytryptamine (5HT) and assess the effects of 5HT on behaviour and mood. However, tryptophan is metabolised primarily along the oxidative kynurenine pathway. In this study a 6 g oral tryptophan load was administered to 15 healthy volunteers and the levels of kynurenines and lipid peroxidation products (indicative of oxidative stress) were measured. The results demonstrate that… CONTINUE READING


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