Corpus ID: 23424319

Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.

@article{Oxenkrug2010TryptophanKM,
  title={Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.},
  author={G. Oxenkrug},
  journal={The Israel journal of psychiatry and related sciences},
  year={2010},
  volume={47 1},
  pages={
          56-63
        }
}
  • G. Oxenkrug
  • Published 2010
  • Medicine
  • The Israel journal of psychiatry and related sciences
  • The original 1969 Lancet paper proposed in depression the activity of liver tryptophan-pyrrolase is stimulated by raised blood corticosteroids levels, and metabolism of tryptophan is shunted away from serotonin production, and towards kynurenine production. Discovery of neurotropic activity of kynurenines suggested that up-regulation of the tryptophan-kynurenine pathway not only augmented serotonin deficiency but also underlined depression-associated anxiety, psychosis and cognitive decline… CONTINUE READING
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