Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area

@article{Soares2007TryptophaninducedCF,
  title={Tryptophan-induced central fatigue in exercising rats is related to serotonin content in preoptic area},
  author={Danusa D Soares and C{\^a}ndido C. Coimbra and Umeko Marubayashi},
  journal={Neuroscience Letters},
  year={2007},
  volume={415},
  pages={274-278}
}
To assess the effects of increased hypothalamic tryptophan (TRP) availability on 5-HT content in preoptic area on thermoregulation and work production during exercise on treadmill, 20.3 microM of L-TRP (n=7) or 0.15M NaCl (n=6) was injected into the lateral cerebral ventricle of male Wistar rats immediately before the animals started running (18 m min(-1) 5% inclination). Exercise time to fatigue (min), and workload (kgm) were analysed. Core temperature was measured by telemetry. At fatigue… CONTINUE READING

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