Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland.

@article{Barbosa2008TryptophanHI,
  title={Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland.},
  author={Roseli Barbosa and Julieta Helena Scialfa and Ilza Mingarini Terra and Jos{\'e} Cipolla-Neto and Val{\'e}rie Simonneaux and Solange Castro Afeche},
  journal={Life sciences},
  year={2008},
  volume={82 9-10},
  pages={529-35}
}
Calcium is an important second messenger in the rat pineal gland, as well as cAMP. They both contribute to melatonin synthesis mediated by the three main enzymes of the melatonin synthesis pathway: tryptophan hydroxylase, arylalkylamine N-acetyltransferase and hydroxyindole-O-methyltransferase. The cytosolic calcium is elevated in pinealocytes following alpha(1)-adrenergic stimulation, through IP(3)-and membrane calcium channels activation. Nifedipine, an L-type calcium channel blocker, reduces… CONTINUE READING

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