Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls

@article{Ono2002TryptophanHI,
  title={Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls},
  author={Hisae Ono and Osamu Shirakawa and Noboru Kitamura and Tasuku Hashimoto and Naoki Nishiguchi and Akiyoshi Nishimura and Hideyuki Nushida and Yasuhiro Ueno and Kiyoshi Maeda},
  journal={Molecular Psychiatry},
  year={2002},
  volume={7},
  pages={1127-1132}
}
Several lines of evidence suggest that a partly genetically controlled serotonergic dysfunction is involved in the biological pathogenesis of suicide. In this study, we measured tryptophan hydroxylase (TPH) immunoreactivity as a pre-synaptic marker, and serotonin receptor 2A (5HT2A receptor) density as a post-synaptic marker in the serotonergic system in 10 postmortem brains of suicide victims. We also examined whether TPH gene polymorphisms (A218C and A-6526G polymorphisms) could affect TPH… CONTINUE READING
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