Tryptophan hydroxylase gene associated with paroxetine antidepressant activity.

  title={Tryptophan hydroxylase gene associated with paroxetine antidepressant activity.},
  author={Alessandro Serretti and Raffaella Zanardi and Cristina Cusin and D. Rossini and Cristina Lorenzi and Enrico Smeraldi},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={11 5},
The possible association of the A218C tryptophan hydroxylase (TPH) gene variant with the antidepressant activity of paroxetine was investigated in a sample of 121 inpatients affected by a major depressive episode and treated with paroxetine 20-40 mg with either placebo or pindolol in a double blind design for 4 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. TPH allelic variants were determined in each subject using a PCR-based… CONTINUE READING


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