Tryptophan catabolism in IDO+ plasmacytoid dendritic cells.

  title={Tryptophan catabolism in IDO+ plasmacytoid dendritic cells.},
  author={Francesca Fallarino and Stefania Gizzi and Paolo Mosci and Ursula Grohmann and Paolo Puccetti},
  journal={Current drug metabolism},
  volume={8 3},
Plasmacytoid dendritic cells (pDCs) represent a specialized cell population that produces large amounts of type I interferons, the so-called natural interferon-producing cells. Recently, murine and human pDCs have been credited with a unique ability to express indoleamine 2,3-dioxygenase (IDO) and to mediate immunosuppression in specific settings. This suggests an important role for IDO-expressing pDCs in controlling the balance of inflammation and tolerance. Here we review recent advances in… CONTINUE READING
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