Tryptophan availability selectively limits NO-synthase induction in macrophages.

@article{Chiarugi2003TryptophanAS,
  title={Tryptophan availability selectively limits NO-synthase induction in macrophages.},
  author={Alberto Chiarugi and Elisabetta Rovida and Persio Dello Sbarba and Flavio Moroni},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={73 1},
  pages={172-7}
}
We studied the effects of tryptophan (TRP) availability on the synthesis and release of nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) in interferon-gamma (IFN-gamma)-activated murine macrophages of the BAC1.2F5 cell line. IFN-gamma (100 U/ml) not only increased the synthesis and release of NO and TNF-alpha from these cells but also induced… CONTINUE READING