Tryptophan availability, 5ht synthesis and 5HT function

  title={Tryptophan availability, 5ht synthesis and 5HT function},
  author={Simon N. Young and Karen L. Teff},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
1. Tryptophan increases 5HT synthesis, but the extent to which it increases 5HT release and therefore 5HT function is unclear. 2. The possibility that increased 5HT levels will lead to increased 5HT release is enhanced when 5HT neurons are firing at a higher rate. The rate of firing of 5HT neurons is increased as the level of behavioral arousal increases. Thus, altered tryptophan levels will be more likely to influence brain function at higher levels of arousal. 3. In the rat, tryptophan… CONTINUE READING

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