Tryptophan and thiosemicarbazide derivatives: design, synthesis, and biological evaluation as potential β-d-galactosidase and β-d-glucosidase inhibitors

Abstract

Glycosidases, including β-d-galactosidase and β-d-glucosidase, are involved in a range of metabolic disorders, such as cancer, viral or bacterial infections, and diabetes. Previously, we scanned the pharmacophoric space of these enzymes and had a self-consistent and predictive quantitative structure–activity relationship that was used to identify several… (More)
DOI: 10.1007/s00044-014-1314-4

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