Tryptophan and the control of plasma glucose concentrations in the rat.

@article{Smith1977TryptophanAT,
  title={Tryptophan and the control of plasma glucose concentrations in the rat.},
  author={Stephen J. Smith and C L Pogson},
  journal={The Biochemical journal},
  year={1977},
  volume={168 3},
  pages={495-506}
}
1. Injection of L-tryptophan (750 mg/kg body wt.) led to pronounced hypoglycaemia in fed and 48 h-starved rats. 2. The hypoglycaemic effect is blocked by pretreament with p-chlorophenylalanine, compound MK-486 [Carbidopa: L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate] or methysergide, and potentiated by pargyline. 3. 5-Hydroxy-L-tryptophan is more potent and induces a more rapid hypoglycaemia than does tryptophan. Other tryptophan metabolites were not associated with… CONTINUE READING

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2 Excerpts

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