Tryptophan and depression: can diet alone be the answer?

  title={Tryptophan and depression: can diet alone be the answer?},
  author={Nerissa Soh and Garry J Walter},
  journal={Acta Neuropsychiatrica},
  pages={3 - 11}
Objective: To compare the scientific content of recent general media articles on tryptophan, diet and depression, with recent empirical research into dietary manipulation of tryptophan published in the scientific literature. Method: A review of the recent empirical research into the role of tryptophan in depression, focusing on dietary methods to influence tryptophan levels. In parallel, a review of recent articles in the general English language media regarding tryptophan and mood. Results… 
Tryptophan Intake in the US Adult Population Is Not Related to Liver or Kidney Function but Is Associated with Depression and Sleep Outcomes.
Levels of tryptophan intake in the US population appear to be safe as shown by the absence of abnormal laboratory findings, and most health- and safety-related biochemical markers of liver function, kidney function, and carbohydrate metabolism were not significant.
The effects of dietary tryptophan on affective disorders.
Dietary supplement drug therapies for depression.
  • R. Howland
  • Medicine
    Journal of psychosocial nursing and mental health services
  • 2012
Of the five products reviewed in this article, only omega-3 fatty acids and SAM-e have sufficient supporting evidence for their efficacy to warrant safe use.
A Mood Point …
This issue’s Intervention Insights section introduces the concept of ‘mind-emptiness’ as part of meditation and its relation to mindfulness and provides a practical solution for dysphagia, albeit in the context of neuropsychiatry.
Associations Between Disordered Microbial Metabolites and Changes of Neurotransmitters in Depressed Mice
These results indicated that CUMS-induced disturbances of microbial metabolites (especially amino acids) might affect the levels of neurotransmitters in prefrontal cortex and then caused the onset of depression.
Pilates Exercises Influence on the Serotonin Hormone, Some Physical Variables and the Depression Degree in Battered Women
2 Abstract: The purpose of the study is to identify the Pilates exercises program impact on the serotonin hormone and some physical variables which represented in the (legs and back muscles strength,
Saliva metabolome alterations after acute stress
This work uses a longitudinal approach to characterise the acute systemic impact of major psychological stress in a pig model and suggests candidate biomarkers with potential roles in stress-related disorders.
Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications
The main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology.
The Effect of Cognitive-behavior Modification and Feeding Behavior on Serotonin Levels and Depression Symptoms
Running Title Educational Program of Cognitive-behavior Modification and Feeding Behavior and Depression : Use your device to scan and read the article online
The present study was conducted to study the impact of serotonin, tryptophan and Optifeed adding in drinking water on behavior characterize, body performance, sensory evaluation of breast and thigh


Association of dietary amino acids with low mood
Dietary intake of lysine and serine was associated with risk of hospital treatment due to major depressive disorder but these associations disappeared after excluding from analysis those who had reported depressed mood at study entry.
The effect of a nutritional source of tryptophan on dieting-induced changes in brain 5-HT function
While TRP treatment did not increase fasting TRP availability it may have modified the effect of dieting on brain 5-HT function, and further studies will be needed to see if this effect of TRP has consequences for the effectiveness of diets as means of weight control.
Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjects.
There was no evidence of mood disturbance during ATD in any subject, which may imply less sensitivity to acute disturbance of the 5HT system than in younger recovered patients.
Effect of different tryptophan sources on amino acids availability to the brain and mood in healthy volunteers
Significantly faster and greater increases in plasma TRP/LNAA were found after HPROT than after ALAC, and the use of a tryptophan-rich hydrolyzed protein source may be more adequate to increase brain tryPTophan and 5-HT function compared with intact alpha-lactalbumin protein or pure tryptphan.
Macronutrient intake, plasma large neutral amino acids and mood during weight-reducing diets
Results suggest that group differences are related to differences in carbohydrate intake and it is hypothesized that impairment of central serotonergic function due to reduced tryptophan availability can prompt mood deterioration in situations of relatively low carbohydrate intake.
Acute tryptophan depletion. Part II: clinical effects and implications.
Following from the initial use of ATD in subjects with depressive illness, studies of anxiety disorders and other psychiatric illnesses have been reported and Acute tryptophan depletion remains a useful psychiatric research tool.
The 1989 Borden Award Lecture. Some effects of dietary components (amino acids, carbohydrate, folic acid) on brain serotonin synthesis, mood, and behavior.
  • S. Young
  • Biology, Psychology
    Canadian journal of physiology and pharmacology
  • 1991
Results suggest that low serotonin can cause lowered mood and increased aggression, but that it is probably not involved in any simple way in carbohydrate craving.
The effects of nutrients on mood
A recent major theory was that a meal high in carbohydrate increased the rate that tryptophan enters the brain, leading to an increase in the level of the neurotransmitter serotonin that modulates mood, but this is unlikely to be of significance following the eating of any typical meal.
Acute Tryptophan Depletion. Part I: Rationale and Methodology
The rationale behind ATD is described, the rationale behind this technique is described and detail on how it is applied in research settings is provided, supporting the specificity of this method.
Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers
Evidence is provided that TRP supplementation in women induces a positive bias in the processing of emotional material that is reminiscent of the actions of serotonergic antidepressants, which lends support to the use of TRP as a nutritional supplement in people with mild depression or for prevention in those at risk.