Tryptophan-Derived Metabolites Are Required for Antifungal Defense in the Arabidopsis mlo2 Mutant1[C][W][OA]

@article{Consonni2009TryptophanDerivedMA,
  title={Tryptophan-Derived Metabolites Are Required for Antifungal Defense in the Arabidopsis mlo2 Mutant1[C][W][OA]},
  author={Chiara Consonni and Paweł Bednarek and Matt Humphry and Fedra Francocci and Simone Ferrari and Anne Harzen and Emiel Ver Loren van Themaat and Ralph Panstruga},
  journal={Plant Physiology},
  year={2009},
  volume={152},
  pages={1544 - 1561}
}
Arabidopsis (Arabidopsis thaliana) genes MILDEW RESISTANCE LOCUS O2 (MLO2), MLO6, and MLO12 exhibit unequal genetic redundancy with respect to the modulation of defense responses against powdery mildew fungi and the control of developmental phenotypes such as premature leaf decay. We show that early chlorosis and necrosis of rosette leaves in mlo2 mlo6 mlo12 mutants reflects an authentic but untimely leaf senescence program. Comparative transcriptional profiling revealed that transcripts of… Expand
Key Components of Different Plant Defense Pathways Are Dispensable for Powdery Mildew Resistance of the Arabidopsis mlo2 mlo6 mlo12 Triple Mutant
TLDR
It is suggested that a broad and fast activation of immune responses in mlo2 mlo6 mlo12 plants can compensate for the lack of single or few defense pathways. Expand
Arabidopsis mlo3 mutant plants exhibit spontaneous callose deposition and signs of early leaf senescence
TLDR
It is hypothesized that de-regulated callose deposition in mlo3 genotypes is the result of a subtle transient aberration of salicylic acid-jasmonic acid homeostasis during development, a phenotype that is reminiscent of mlo2 mutant plants. Expand
Arabidopsis mlo3 mutant plants exhibit spontaneous callose deposition and signs of early leaf senescence
TLDR
Arabidopsis thaliana mlo3 mutant plants are not affected in pathogen infection phenotypes but—reminiscent of mlo2 mutant plants—exhibit spontaneous callose deposition and signs of early leaf senescence, hypothesized to be the result of a subtle transient aberration of salicylic acid-jasmonic acid homeostasis during development. Expand
The pepper MLO gene, CaMLO2, is involved in the susceptibility cell-death response and bacterial and oomycete proliferation.
TLDR
The results suggest that CaMLO2 is involved in the susceptibility cell-death response and bacterial and oomycete proliferation in pepper and Arabidopsis. Expand
Tryptophan-derived secondary metabolites in Arabidopsis thaliana confer non-host resistance to necrotrophic Plectosphaerella cucumerina fungi.
TLDR
Findings imply differential contributions of antimicrobials in non-host resistance to necrotrophic and biotrophic pathogens. Expand
A critical role for Arabidopsis MILDEW RESISTANCE LOCUS O2 in systemic acquired resistance
TLDR
It is concluded that MLO2 acts as a critical downstream component in the execution of SAR to bacterial infection, being required for the translation of elevated defense responses into disease resistance. Expand
The powdery mildew-resistant Arabidopsis mlo2 mlo6 mlo12 triple mutant displays altered infection phenotypes with diverse types of phytopathogens
TLDR
The results of this study strengthen the notion that mutations in genes MLO2, MLO6 and MLO12 not only restrict powdery mildew colonization, but also affect interactions with a number of other phytopathogens. Expand
Regulatory and Functional Aspects of Indolic Metabolism in Plant Systemic Acquired Resistance.
TLDR
Investigation of the functional role and regulatory characteristics of indolic metabolism in Arabidopsis systemic acquired resistance (SAR) triggered by the bacterial pathogen Pseudomonas syringae suggests that systemically elevated indoles are dispensable for SAR and associated systemic increases of salicylic acid. Expand
Molecular characterization of mlo-based powdery mildew resistance and the role of heterotrimeric G-protein signaling in Arabidopsis defense
TLDR
Metabolomic analysis performed in this study indicate that the adapted powdery mildew fungus, Golovinomyces orontii, is able to suppress the accumulation of the defense-relevant indolic glucosinolate, 4MI3G (4-methoxyindol-3-ylmethylglucosinol) in Arabidopsis, thereby inhibiting the PEN2-dependent glucos inolate defense pathway. Expand
Evidence for Allele-Specific Levels of Enhanced Susceptibility of Wheat mlo Mutants to the Hemibiotrophic Fungal Pathogen Magnaporthe oryzae pv. Triticum
TLDR
Evidence is found for allele-specific levels of enhanced susceptibility of Tamlo plants to the hemibiotrophic wheat pathogen MoT, with stronger powdery mildew resistance correlated with more invasive growth by the blast pathogen. Expand
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References

SHOWING 1-10 OF 91 REFERENCES
The Barley MLO Modulator of Defense and Cell Death Is Responsive to Biotic and Abiotic Stress Stimuli1
TLDR
Mlo transcript abundance increases in response to Bgh, rice (Oryza sativa) blast, wounding, paraquat treatment, a wheat powdery mildew-derived carbohydrate elicitor, and during leaf senescence, which suggests a broad involvement of Mlo in cell death protection and in responses to biotic and abiotic stresses. Expand
Correlation of defense gene induction defects with powdery mildew susceptibility in Arabidopsis enhanced disease susceptibility mutants.
TLDR
Comparison of the PR gene induction patterns in response to E. orontii in the various mutants and in the nahG transgenics suggests the existence of NPR1-independent salicylate-dependent and NPR2-independentSalicylates-independent defense gene activation pathways. Expand
Requirement of functional ethylene-insensitive 2 gene for efficient resistance of Arabidopsis to infection by Botrytis cinerea.
TLDR
The data support the conclusion that ethylene-controlled responses play a role in resistance of Arabidopsis to some but not all types of pathogens. Expand
Arabidopsis PEN3/PDR8, an ATP Binding Cassette Transporter, Contributes to Nonhost Resistance to Inappropriate Pathogens That Enter by Direct Penetration[W][OA]
Arabidopsis thaliana is a host to the powdery mildew Erysiphe cichoracearum and nonhost to Blumeria graminis f. sp hordei, the powdery mildew pathogenic on barley (Hordeum vulgare). Screening forExpand
Arabidopsis PAD 3 , a Gene Required for Camalexin Biosynthesis , Encodes a Putative Cytochrome P 450 Monooxygenase
Phytoalexins are low molecular weight antimicrobial compounds that are synthesized in response to pathogen attack. The phytoalexin camalexin, an indole derivative, is produced by Arabidopsis inExpand
Deficiency in phytoalexin production causes enhanced susceptibility of Arabidopsis thaliana to the fungus Alternaria brassicicola.
TLDR
Camalexin production could not be triggered by exogenous application of either salicylate, ethylene or jasmonate and was not, or not strongly, reduced in mutants with defects in perception of these defense-related signal molecules, which appears to be a key determinant in resistance to at least A. brassicicola. Expand
Conserved requirement for a plant host cell protein in powdery mildew pathogenesis
TLDR
A conserved requirement for MLO proteins in powdery mildew pathogenesis in the dicotyledonous plant species Arabidopsis thaliana is demonstrated, suggesting that within the Erysiphales (powdery mildews) the ability to cause disease has been a stable trait throughout phylogenesis. Expand
A Compromised Mlo Pathway Affects the Response of Barley to the Necrotrophic Fungus Bipolaris sorokiniana (Teleomorph: Cochliobolus sativus) and Its Toxins.
TLDR
The hypothesis that the barley Mlo gene product functions as a suppresser of cell death supports the hypothesis that a compromised Mlo pathway is effective for control of biotrophic powdery mildew fungus but not for necrotrophic Bipolaris sorokiniana. Expand
Arabidopsis PAD3, a Gene Required for Camalexin Biosynthesis, Encodes a Putative Cytochrome P450 Monooxygenase
TLDR
The results strongly support the idea that camalexin does not play a major role in plant resistance to P. syringae infection, although it is involved in resistance to a fungal pathogen. Expand
Arabidopsis Auxin Mutants Are Compromised in Systemic Acquired Resistance and Exhibit Aberrant Accumulation of Various Indolic Compounds1[W][OA]
TLDR
Based upon predicted transcriptional networks induced in naive Arabidopsis leaves following avirulent Pseudomonas syringae challenge, it is shown that a variety of auxin mutants compromise the establishment of systemic immunity. Expand
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