Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance

@inproceedings{Ammendola2017TryptaseMC,
  title={Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance},
  author={Michele Ammendola and Rosario Sacco and Giuseppina Vescio and Valeria Zuccal{\`a} and Maria Luposella and Rosa Patruno and Nicola Zizzo and Claudia Gadaleta and Ilaria Marech and Roberta Ruggieri and Ibrahim Kocak and Taner Ozgurtas and Cosmo Damiano Gadaleta and Giuseppe Sammarco and Girolamo Ranieri},
  booktitle={Therapeutic advances in gastroenterology},
  year={2017}
}
BACKGROUND Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via protease-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosphorylation. Nevertheless, no data are… CONTINUE READING