Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.

@article{Schwartz1987TryptaseLA,
  title={Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.},
  author={Lisa Barrie Schwartz and Dean D Metcalfe and Jeffrey S. Miller and Helena M. Earl and Theresa Sullivan},
  journal={The New England journal of medicine},
  year={1987},
  volume={316 26},
  pages={
          1622-6
        }
}
Better methods are needed to assess mast-cell activation in vivo and to distinguish the activation of mast cells from that of basophils. Tryptase, a neutral protease selectively concentrated in the secretory granules of human mast cells (but not basophils), is released by mast cells together with histamine and serves as a marker of mast-cell activation. In 17 patients with systemic mastocytosis, concentrations of tryptase in plasma were linearly related to those of histamine (P less than 0.01… CONTINUE READING

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