Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.

@article{Roman2014TryptasePAR2AI,
  title={Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.},
  author={Kenny Roman and Joseph D. Done and Anthony Schaeffer and Stephen F. Murphy and Praveen Thumbikat},
  journal={Pain},
  year={2014},
  volume={155 7},
  pages={1328-38}
}
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects up to 15% of the male population and is characterized by pelvic pain. Mast cells are implicated in the murine experimental autoimmune prostatitis (EAP) model as key to chronic pelvic pain development. The mast cell mediator tryptase-β and its cognate receptor protease-activated receptor 2 (PAR2) are involved in mediating pain in other visceral disease models. Prostatic secretions and urines from CP/CPPS patients were examined… CONTINUE READING
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Proteaseactivated receptor 2 sensitizes the capsaicin receptor transient receptor Please cite this article in press as: Roman K et al. Tryptase-PAR2 axis in experim PAIN

  • S Amadesi, J Nie, +10 authors NW. Bunnett
  • J Neurosci
  • 2014
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