Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine

  title={Tryptamine, N,N-Dimethyltryptamine, N,N-Dimethyl-5-hydroxytryptamine and 5-Methoxytryptamine in Human Blood and Urine},
  author={Fr. Franzen and H. Gross},
TRYPTAMINE is a normal constituent of human urine1–5; about 30–120 µg of the amine are excreted per 24 h. In blood, tryptamine has hitherto been demonstrated only qualitatively and under pathological conditions in a carcinoid patient6. There is no information about an occurrence of N,N-dimethyltryptamine in human beings. N,N-dimethyl-5-hydroxytryptamine (= Bufotenin) was demonstrated qualitatively as a constituent of normal human urine4,7; in children an excretion of 0–0.03 µg amine/100 mg… Expand
Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptamine and N,N-Dimethylaminopropyltryptamine
The demonstration of noncompetitive mechanisms for INMT inhibition implies the presence of an inhibitory allosteric site, which may illuminate new biochemical pathway(s) underlying the biology of INMT. Expand
A peptide-like inhibitor of N-methyltransferase in rabbit brain.
It is suggested that these peptides may control in vivo the activity of the non-specific N-methyltransferase against tryptamine and serotonin. Expand
Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates.
The reported extension of half-life and potentiation of DMT behavioral effects by iproniazid may be due to inhibition of NMT and DMT-NO formation rather than inhibition of monoamine oxidase. Expand
Indolethylamine-N-methyltransferase Polymorphisms: Genetic and Biochemical Approaches for Study of Endogenous N,N,-dimethyltryptamine
All reported SNPs in INMT were amassed from genetic and biochemical literature and genomic databases to consolidate a blueprint for future studies aimed at elucidating whether DMT plays a physiological role. Expand
A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010.
A critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids addresses the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT. Expand
N-methylated tryptamine derivatives in citrus genus plants: identification of N,N,N-trimethyltryptamine in bergamot.
The identification of N,N,N-trimethyltryptamine at a relatively high level in leaves suggests a possible role in a physiological mechanism of plant defense. Expand
Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method.
A method for the solid-phase extraction (SPE) and liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric-mass spectrometric-isotope dilution (LC-APcI-MS-MS-ID) analysis ofExpand
The hallucinogenic world of tryptamines: an updated review
A comprehensive update on tryptamine hallucinogens, concerning their historical background, prevalence, patterns of use and legal status, chemistry, toxicokinetics, toxicodynamics and their physiological and toxicological effects on animals and humans is provided. Expand
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
Results show for the first time that the rat brain is capable of synthesizing and releasing DMT at concentrations comparable to known monoamine neurotransmitters and raise the possibility that this phenomenon may occur similarly in human brains. Expand
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter
High binding-to-uptake ratios support the hypothesis that the tryptamines are transporter substrates, not uptake blockers, at both SERT and VMAT2, and indicate that there are separate substrate and inhibitor binding sites within these transporters. Expand


Separation and characterization of urinary indoles resembling 5-hydroxytryptamine and tryptamine.
  • R. Rodnight
  • Chemistry, Medicine
  • The Biochemical journal
  • 1956
The ion-exchange resin Zeo-Karb 226 has been used to examine human urine for the presence of 5-hydroxytryptamine and related indoles, a carboxylic acid-type resin with similar properties to the resin Amberlite IRC 50, recently used to determine histamine in rat urine. Expand
It is suggested that study of the excretion of amines in the urine of children who are mentally defective or mentally ill, and comparison with the pattern of urinary amine excretion in normal children, may provide clues to the mechanisms of certain forms of cerebral dysfunction. Expand
Studies on the metabolism of aromatic amines in relation to altered thyroid function in man.
Withdrawal of thyroid hormone from the hypothyroid patient was associated with increased tissue MAO activity and a slight lowering of urinary tyramine, and measurements of plasma amino acids indicated a unique elevation of plasma tyrosine levels in thyrotoxic states. Expand
N-Methylmetanephrine: Excretion by Juvenile Psychotics
Urinary excretion of bufotenin and of 3,4-dimethoxyphenylethylamine, each of which has been reported elevated in some adult schizophrenics, was not unusual in these children. Expand
Urinary 5-methoxytryptamine in patients with rheumatic fever.
The present report describes an abnormal product of tryptophan metabolism isolated from the urine of rheumatic subjects, based on a previous observation that the tetrahydrofurfuryl ester of nicotinic acid elicited a different response in the skin of patients suffering from active rhematic fever than in theSkin of nonrheumatic patients. Expand
Identification and assay of urinary tryptamine: application as an index of monoamine oxidase inhibition in man.
The level of urinary tryptamine is shown to be a sensitive index of monoamine oxidase inhibition in man and a simple fluorometric method for its measurement in urine is described. Expand
Tryptamine in the Blood and Urine of a Patient with a Carcinoid Tumour
Variants of the carcinoid syndrome have, however, been described in which the major secretion is 5-hydroxytryptophan1. Expand