Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel.

@article{Solaro1992TrypsinsensitiveRI,
  title={Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel.},
  author={C R Solaro and Christopher J Lingle},
  journal={Science},
  year={1992},
  volume={257 5077},
  pages={
          1694-8
        }
}
Most calcium-activated potassium channels couple changes in intracellular calcium to membrane excitability by conducting a current with a probability that depends directly on submembrane calcium concentration. In rat adrenal chromaffin cells, however, a large conductance, voltage- and calcium-activated potassium channel (BK) undergoes rapid inactivation, suggesting that this channel has a physiological role different than that of other BK channels. The inactivation of the BK channel, like that… CONTINUE READING

Citations

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A limited access compartment between the pore domain and cytosolic domain of the BK channel.

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Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells.

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BK Channels in the Central Nervous System.

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