Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model.

Abstract

Immune-mediated injury by the protease-activated receptor-2-interleukin-8 (PAR-2-IL8) pathway may underlie the development of gastroesophageal reflux disease (GERD). However, the localization of PAR-2 and the mechanism of PAR-2 activation remain unclear. This study aimed to address these questions on an esophageal stratified squamous epithelial model and in… (More)
DOI: 10.1152/ajpgi.00220.2012

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Cite this paper

@article{Shan2012TrypsinIE, title={Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model.}, author={Jing Shan and Tadayuki Oshima and Xin Chen and Hirokazu Fukui and Jiro Watari and Hiroto Miwa}, journal={American journal of physiology. Gastrointestinal and liver physiology}, year={2012}, volume={303 10}, pages={G1105-12} }