Trypsin and rosmarinic acid reduce the toxicity of Micrurus fulvius venom in mice.

  title={Trypsin and rosmarinic acid reduce the toxicity of Micrurus fulvius venom in mice.},
  author={Jennifer L. Parker-Cote and Dorcas P. O'Rourke and Samara N. Miller and Kori L. Brewer and Matthew D. Rosenbaum and William J. Meggs},
  journal={Clinical toxicology},
  volume={52 2},
UNLABELLED CONTEXT. Antivenom is expensive and not always available, so alternative treatments are being investigated. OBJECTIVE. The efficacy of trypsin or rosmarinic acid (RA) in treating Micrurus fulvius in a murine model is determined. MATERIALS AND METHODS. DESIGN randomized controlled blinded study. SUBJECTS Fifty mice (20-30 g). Study groups: Intraperitoneal injections of: 1) 2 mg/kg M. fulvius venom (approximately twice the LD50 for mice; n = 10); 2) 2 mg/kg M. fulvius venom… CONTINUE READING

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