Trypsin activation pathway of rotavirus infectivity.

  title={Trypsin activation pathway of rotavirus infectivity.},
  author={Carlos F Arias and Pedro A. Romero and V. Gonz{\'a}lez {\'A}lvarez and Susana Gonz{\'a}lez L{\'o}pez},
  journal={Journal of virology},
  volume={70 9},
The infectivity of rotaviruses is increased by and most probably is dependent on trypsin treatment of the virus. This proteolytic treatment specifically cleaves VP4, the protein that forms the spikes on the surface of the virions, to polypeptides VP5 and VP8. This cleavage has been reported to occur in rotavirus SA114fM at two conserved, closely spaced arginine residues located at VP4 amino acids 241 and 247. In this work, we have characterized the VP4 cleavage products of rotavirus SA114S… CONTINUE READING