Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function.

@article{Alphey2003TryparedoxinsFC,
  title={Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function.},
  author={Magnus S. Alphey and Mads Gabrielsen and Elena Micossi and Gordon A. Leonard and Se{\'a}n M. McSweeney and Raimond B G Ravelli and Emmanuel T{\'e}taud and Alan H. Fairlamb and Charles S. Bond and William N. Hunter},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 28},
  pages={25919-25}
}
Tryparedoxin (TryX) is a member of the thioredoxin (TrX) fold family involved in the regulation of oxidative stress in parasitic trypanosomatids. Like TrX, TryX carries a characteristic Trp-Cys-Xaa-Xaa-Cys motif, which positions a redox-active disulfide underneath a tryptophan lid. We report the structure of a Crithidia fasciculata tryparedoxin isoform (CfTryX2) in two crystal forms and compare them with structures determined previously. Efforts to chemically generate crystals of reduced TryX1… CONTINUE READING
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Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography

  • K. Cowtan
  • SERC Daresbury Laboratory,
  • 1994
1 Excerpt

Structure and Reactivity of Tryparedoxin

  • Bond, William N. Hunter McSweeney, +7 authors M Sean
  • J. Biol. Chem. 10.1074/jbc.M301526200
  • 1993
1 Excerpt

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