Trypanothione biosynthesis in Leishmania major.

  title={Trypanothione biosynthesis in Leishmania major.},
  author={Sandra L. Oza and Matthew P Shaw and Susan Wyllie and Alan H. Fairlamb},
  journal={Molecular and biochemical parasitology},
  volume={139 1},
Trypanothione plays a crucial role in regulation of intracellular thiol redox balance and in defence against chemical and oxidant stress. Crithidia fasciculata requires two enzymes for the formation of trypanothione, namely glutathionylspermidine synthetase (GspS; EC and a glutathionylspermidine-dependent trypanothione synthetase (TryS; EC, whereas Trypanosoma cruzi and Trypanosoma brucei use a broad-specificity trypanothione synthetase to make trypanothione from glutathione… CONTINUE READING