Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system.

@article{Dubois2005TrypanosomesEA,
  title={Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system.},
  author={Melissa E. Dubois and Karen P. Demick and John M. Mansfield},
  journal={Infection and immunity},
  year={2005},
  volume={73 5},
  pages={2690-7}
}
Host resistance to African trypanosomiasis is partially dependent on an early and strong T-independent B-cell response against the variant surface glycoprotein (VSG) coat expressed by trypanosomes. The repetitive array of surface epitopes displayed by a monotypic surface coat, in which identical VSG molecules are closely packed together in a uniform architectural display, cross-links cognate B-cell receptors and initiates T-independent B-cell activation events. However, this repetitive array of… CONTINUE READING

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